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Published results from a 2017 dose-ranging trial demonstrated that ARA-290 at 4 mg subcutaneously daily for 28 days met its primary endpoint: a significant placebo-corrected increase in corneal nerve fiber area an objective biomarker of small nerve fiber regeneration measured by confocal microscopy

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The reason is that the source of these compounds is derived from living organisms through enzymatic polymerization, forming high molecular weight macromolecules

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