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Moreover, a minor proportion of this agent can be metabolized within the liver by the cytochrome P450 enzymes (primarily by CYP2E1) to NAPQI, which is detoxified by conjugation and excreted in the glutathione or NAC forms ( Figure 2 )
While glutathione is primarily known for its skin-brightening effects, its antioxidant and anti-inflammatory properties may help reduce acne and blemishes
Collectively, these findings suggest that nose-to-brain delivery of L-penetratin/insulin was effective in the early stage of cognitive dysfunction and that nasal administration of L-penetratin/exendin-4 with insulin boosted therapeutic effect of exendin-4 in the progressive memory dysfunction in vivo
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