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If GLP-1R and GIPR continuously modulate each others signaling through dynamic heterodimerization and receptor balance, then the pharmacology of dual agonists may depend not only on ligand binding, but also on receptor expression and trafficking within target tissues
Those who may have certain medical conditions, such as a history of pancreatitis or medullary thyroid carcinoma, should avoid these medications
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Diabetes Care (2017) 40(3):32531
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