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Severe gastrointestinal adverse effects (persistent vomiting or diarrhoea) can lead to dehydration and, in susceptible individuals, acute kidney injury
"Providers prescribing GLP-1s want their patients to have nutrition guidance, side-effect support, and behavioral tools but the structure of primary care doesn't always make that possible
Gaining insight into its mechanisms and dosing is key to seeing how it compares to other options
Back Chaiborn, C (1 Aug 2011) 'Masters of metabolism: Matthias Tschp and Richard DiMarchi', The Journal of Clinical Investigation , 121/8, 2952
Orforglipron met the trials other goals of reducing patients hemoglobin A1c, a measure of blood sugar levels
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