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GLP-1 RAs mimic the endogenous incretin hormone secreted by intestinal L-cells
Proven Efficacy: Clinical trials have shown that high-dose oral semaglutide produces weight loss results comparable to the injectable versions
Another review looked at how well different GLP-1 receptor agonists worked when added to metformin in people with type 2 diabetes
In the group of animals receiving separate injections of icodec and semaglutide, one animal was excluded from the semaglutide pharmacokinetic results due to being an outlier with only 1020% of semaglutide concentrations relative to the rest of the group
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