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Based on the present steady-state data, we compared the developed population PK model to a one-compartment PK model similar to the one estimated in the phase 3 analysis [6] with almost identical results
Period changes
Timing patterns across both routes
In 2023, the EMA's Pharmacovigilance Risk Assessment Committee (PRAC) reviewed reports of thyroid cancer and pancreatitis associated with GLP-1 receptor agonists but concluded there was no causal link for thyroid cancer and did not recommend changes to prescribing guidance based on pancreatic cancer concerns
the long-acting GLP-1 agent liraglutide were analyzed in two independent head-to-head comparison studies [17, 18]
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