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Targeting Ventilatory Instability and High Loop Gain About one-third of patients with OSA have increased ventilatory instability or high loop gain, which is an exaggerated change in ventilatory drive in response to relatively small changes in the partial pressure of carbon dioxide (PaCO 2 ) levels detected by chemoreceptors [12]

Treating certain nutrient deficiencies

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NNMT is a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, spending SAM and diverting nicotinamide away from the NAD+ salvage pathway

The decision on this motion is pending