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Before human translation, essential parameters to define: optimal dosing, infusion/administration route, frequency, biomarkers to monitor (senescent cell burden, inflammatory cytokines, organ function), long-term follow-up for adverse outcomes (especially tumour risk)

Before designing any stacking protocol, researchers should understand both the individual effects of each compound and the potential interactions between them

Iron death, characterized by oxidative stress due to intracellular Fe2+ accumulation, leading to large amounts of ROS production, ultimately results in cell death (161) and contributes to various cardiovascular diseases including atherosclerosis, I/R injury, HF, myocardial infarction and adriamycin cardiomyopathy (162)

The MTT solution was removed and DMSO (150 L) was added to dissolve formazan

BPC-157 has the largest in vivo dataset across Achilles tendon, medial collateral ligament, and quadriceps models