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Here, I briefly explain the evolution of drugs of this kind, analyze the residue discrepancies between tirzepatide and endogenous incretins, summarize some existing strategies for prolonging half-life, and present suggestions for future research, mainly involving biased functions

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In laboratory and pre-clinical settings, DSIP has been studied as a uniquely multifunctional endogenous regulatory neuropeptide across sleep, stress, neuroendocrine, neuroprotection, and geroprotective research applications: Sleep biology delta-wave SWS promotion, sleep homeostasis modulation, sleep efficiency and sleep latency research Sleep EEG research delta-wave induction, SWS vs REM sleep architecture, and sleep stage analysis via polysomnography Sleep neuromodulator pharmacology DSIP vs sedatives and hypnotics