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2023 [cited 2025 Jan 6]
Phase 3 TRIUMPH-4 trial results The Phase 3 TRIUMPH-4 trial enrolled 445 adults with obesity or overweight and knee osteoarthritis, testing 9 mg and 12 mg maintenance doses over 68 weeks
The reason for spending a full month at each dose level is that semaglutide takes approximately four to five weeks to reach steady-state blood concentrations at any given dose
Although oral semaglutide was projected to increase costs over the long term, these were partially offset by cost savings from avoidance of diabetes-related complications, and ICERs in the base case analyses and in the majority of wide-ranging sensitivity analyses were estimated to be under the commonly used willingness-to-pay threshold of EUR 30,000 per QALY gained in Portugal
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