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Blue Cross Blue Shield plans generally have very strict policies against covering off-label uses, especially for expensive medications

Pairing a GHRH analogue with a GHS-R1a agonist is a long-standing design in secretagogue research, following the work of Bowers and colleagues showing that the two classes produce a greater combined response than either alone

That said, the side effect profile overlaps significantly with GLP-1 agonistsGI symptoms like nausea, vomiting, and diarrhea are still common, especially during dose escalation

Potential heterogeneity of effects was evaluated using a Wald test

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