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Before injecting, participants should: Wash hands thoroughly with soap and water Allow the device to reach room temperature (if stored in the fridge) for the time specified in the trial instructions typically around 30 minutes, though this may vary by device Inspect the solution it should be clear and colourless

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Every major clinical trial in medicine must, prior to the enrollment of the first person into the study, declare what will constitute a positive trial

Pooled estimates were adjusted into 95% confidence intervals (CIs) according to Knapp and Hartung (2003)

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