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Given the compounds increasing availability, popularity, and its regulatory controversies, we sought to assess the breadth and quality of preclinical and clinical data supporting its use in musculoskeletal medicine

These metabolites include cytochrome P450 metabolites of arachidonic acids 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids, cyclooxygenase metabolites prostaglandin E2, prostaglandin I2, and thromboxane A2, and lipoxygenase metabolites leukotrienes, hydroxyeicosatetraenoic acids, and lipoxins