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Thyroid concerns and cancer risk Both semaglutide and tirzepatide carry a black box warning about medullary thyroid carcinoma (MTC) risk
Immediate effects begin within 24-48 hours, with appetite changes and weight regain typically occurring within 2-4 weeks of discontinuation
Skin brightening and improved skin tone
Dose was defined as the highest dose reached within 12 months after semaglutide initiation
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