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However, Ozempic is less effective than Tirzepatide and may not help patients lose as much weight as they desire

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(2012) and Pluskal et al

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A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia