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doi: 10.1007/s00204-023-03476-6 67 QiuBZandkarimiFBezjianCTReznikESoniRKGuWet al
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The insulin/IGF-1 signaling in mammals and its relevance to research subjects longevity [PMID: 16168602] Laboratory literature summary: The insulin/IGF-1 signaling in mammals and its relevance to research subjects longevity
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No longterm human trials exist
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Specific nutrients highlighted in guidance include vitamin B12, iron, folate, calcium, and vitamin D
3.3 Protein damage and the stress sensing Cells convert heat-induced protein damage into a regulated transcriptional signal through a competitive release mechanism in which the dissociation of HSF1 from inhibitory chaperone complexes serves as a central switch in the stress response (Figure 2a) (Zheng et al., 2016)
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