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Analysis of an independent single-cell/CITE-seq cohort provided supportive evidence for altered T-cell metabolism-related transcriptional programs in TCMR, particularly involving oxidative phosphorylation-related scores
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Transfer learning for drug-target interaction prediction
For example, GLP-1R in adipocytes can directly regulate apoptosis and preadipocyte proliferation by activating the adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP) signaling pathway and various cell signaling cascades, including extracellular signal-regulated kinase (ERK), protein kinase C (PKC), and protein kinase B (AKT) [41,46]
Sustainable weight loss is about long-term metabolic health
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