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The group concluded that considering its substrate specificity and expression in organs such as the brain, kidney and intestine, genetic variations in may be an important contributor to inter-individual variability in drug disposition and central nervous system entry of OATP1A2 substrate drugs (Lee et al
The growing demand for pharmacological tools to support weight loss, beyond traditional lifestyle interventions, reflect a broader shift in how these powerful medications are being used in clinical practice
FOXO signaling appears to have the potential to increase autophagy and proteasomal activity in the heart, thus speeding up the clearing of damaged cells
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