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Dundee300 H57 HM60200 H116 H121 H123 H309 H313 H316 HM56 H307 H310 H311 H118 H120 H122 H312 H315 HM40 H124 H15 100 0 Human Liver CytosolInduction: Little evidence for induction of sulfotransferases in vivo with classicinducers Pb, BHA or 3MC, but PCN does induce (Liu, Klaassen Drug Metab Dispos.24: 85 (1996)

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Vecchiarelli et al., 2022)

Finally, the chemical structure of GSH provides peculiar characteristics ranging from un-susceptibility to proteolysis to redox thiols catalysis

Subsequent cell culture studies revealed that GSSG accumulation, as opposed to GSH reduction, sensitized hepatocytes to TNF killing by reducing the TNF-triggered NF-B activity