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Berberine, for instance, shouldn't be combined with certain diabetes medications without medical supervision
de Pouvourville G, Blin P, Karam P
Indeed, tyrosine-972 in the NPEY motif of IR (numbering relative to human IR-B or +exon 11 isoform), which is phosphorylated following ligand stimulation, serves as a docking site for proteins with a PTB domain, such as IRS-1 and Shc, and mutation of this residue markedly decreases phosphorylation of these receptor substrates and activation of downstream signaling (16, 17)
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