In cell culture assays, elevated endotoxin levels induce non-specific inflammatory signaling, alter cytokine profiles, and trigger premature apoptosis
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Cyclin D1 and P53 upregulations and downregulation P27s can influence HCC HEPA16 cells [98]
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Yi-Shen-Hua-Shi granules mitigate proteinuria and reverse gut microbiota dysbiosis in CKD by increasing Faecalibacterium , Lachnoclostridium , Sutterella , and Lachnospiraceae while reducing Clostridium innocuum and Eggerthella ( Lactobacillaceae and Prevotellaceae whilesuppressing Clostridiaceae , Enterobacteriales , and Micrococcaceae (65)