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The hazard ratios (HRs) comparing tirzepatide to controls were 0.80 (95% CI, 0.571.11) for MACE-4, 0.90 (95% CI, 0.501.61) for cardiovascular death, and 0.80 (95% CI, 0.511.25) for all-cause death
Rapid weight loss may also increase the risk of losing lean muscle mass if patients are not prioritizing protein intake and resistance training
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
Ozempic stimulates insulin release when blood sugar rises and helps limit postprandial glucose spikes
In the withdrawal cohort, regaining half of the lost weight raised insulin resistance by roughly 35% to 40%, and blood pressure rose as weight returned. Taper frameworks combine at least 1.2 g/kg of protein with resistance training before the drug signal fades
