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In the liver and muscle, both in the feeding and fasting states, the free carnitine and total carnitine concentrations in the carnitine supplementation group were significantly higher than in the control group (Fig

Immunohistochemical analysis revealed that treatment with DAPA led to increased expression of Nrf2, HO-1, SLC7A11, GPX4 and FTH-1 as well as decreased expression of TFR-1 compared with the DN group and si-Nrf2 group (Fig

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