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Furthermore, GLP-1 RAs exhibit anti-inflammatory effects, lowering circulating levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and IL-6, while promoting anti-inflammatory mediator production [26]

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TMAO t 1/2 estimates derived from log-linear elimination phase starting after T max were 7.8 1.5 h and 8.6 3.4 h for placebo and pomegranate interventions, respectively, indicating relatively efficient elimination after peak TMAO concentrations