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The metformins value as an OXPHOS inhibitor for cancer treatment remains a subject of contention, and prudence is advisable in its utilization for this purpose ( Since metformin intervention is safe and well-tolerated among patients, determining the most effective dose in terms of beneficial effects and disease prevention is a significant challenge ( 2 should not receive metformin due to the risk of metformin-associated lactic acidosis (MALA) ( 7 Limitation of metformin use Metformin, as a popular drug used in the treatment of T2DM, has its application and benefits in improving glycemic control and metabolism in many patients

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