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2025 Pilot Study IV Safety in Humans The most recent human data is a 2025 pilot study by Lee and Burgess, published in Alternative Therapies in Health and Medicine (PMID: 40131143)

Meaningful increases in cellular glutathione levels and the full performance and immune benefits that come with them typically accumulate over 30 to 90 days of regular use

The abdomen (at least 2 inches away from the navel) is a common site for subcutaneous NAD+ because it has a good layer of subcutaneous fat and tends to be less sensitive