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The prescriber must document clinical justification in the medical record
Wang X, Zhang Y, Hou Y et al (2025) Mechanistic insights into Salidrosides mitochondrial protection via AMPK/Sirt1/HIF-1 pathway in hypoxic HT22 cells
The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
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Nitric oxide is involved in growth regulation and re-orientation of pollen tubes
