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Jiang Y, Cheng DW, Levi E, Singh LP

Significant pigmentation improvement typically appears by month 3

In normal oxidative metabolism, the free radical formation is expected

This feature and its negative charge at physiological pH imply the existence of specific carriers to import GSH from the cytosol to the mitochondrial matrix, where it plays a key role in defense against respiration-induced reactive oxygen species and in the detoxification of lipid hydroperoxides and electrophiles

Rather than stopping entirely, you reduce to a lower maintenance dose that preserves the appetite-suppressing and metabolic benefits while minimizing side effects and cost