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annual kidney function assessment (serum creatinine, estimated glomerular filtration rate, urine albumin-to-creatinine ratio)more frequent if you have existing kidney disease

In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%

Apparently unidirectional polyamine transport by proton motive force in polyamine-deficient Escherichia coli

Thats why medical specialists, pharmacologists, and treating physicians all play distinct roles in proving how the drugs mechanism directly caused harm

While urinary excretion of VC metabolites (oxalate, threonate) maintains systemic balance, prolonged deficiency ( ShacterEet alAscorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo