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Researchers originally investigated this fragment as part of efforts to isolate the lipolytic activity of hGH without the proliferative or metabolic side effects associated with the full molecule

"Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist"

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These agents have a beneficial effect on pancreatic islet function by facilitating the secretion of insulin in response to ambient blood glucose levels and inhibiting glucagon secretion both directly and indirectly

Other prescription weight loss drugs, some with longer histories of use, include Liraglutide, bupropion/naltrexone (contrave), phentermine (in various doses), Phentermine-Topiramate combination (Qysmia), and numerous other GLP-1 agonists or GIP/GLP-1 agonists