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Pernicious anemia was identified in 1855 by Thomas Addison, the English physician best known in the context of Addisons disease

Intranasal administration is valued as a non-invasive means of both systemic and local administration with good bioavailability, rapid onset, and targeted effects on the central nervous system [13, 14]

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This contrast highlights that while our population exhibited uniformity in Vitamin B12 levels across age groups and sexes, the Penninx study points to an increased vulnerability to depression linked to vitamin B12 deficiency, particularly in older adults