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liver steatosis or fat infection by commensal bacteria, need to be evaluated

Low absorption rates due to the digestive process

Since the net charge of CAND is -0.2, resulting in an overall neutral charge, it is difficult for CAND to be effectively transported to the cell nucleus on its own

J Clin Invest 117:21552163 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

Duckworth CA, Watson AJ: Analysis of epithelial cell shedding and gaps in the intestinal epithelium