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Nonetheless, the deletion of Nrf2 prevented the increased expression of NRF2 protein and the induction of NRF2 targets upon Gclc deletion in liver tissue (Fig

Staggering them complicates your ability to assess what's actually working

In fact, as compared with D 4.4 R, not only D 4.7 R seems to be less able to heteromerize with D 2 R (52, 56, 57), but it also seems to be more able to homomerize (56)

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Cells respond to specific signaling intensities, and exceeding optimal ranges doesn't produce proportionally better responses