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Future trials should pair clinical outcomes with peripheral immunophenotyping and neuroinflammatory imaging to document target engagement

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Constipation Slow transit may prolong intestinal contact with biliary metabolites and increase the opportunity for deconjugation and reabsorption

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Also, dosage adjustments may be necessary in patients with significantly reduced kidney function

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J Biochem Mol Biol

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PyEMMA 2: a software package for estimation, validation, and analysis of Markov models

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