semaglutide helps depression from The interplay of gut microbiota, obesity, and depression: insights and interventions GLP-1 diabetes drugs could stop

Analysis of the PLCE1 gene alterations using The Cancer Genome Atlas (TCGA) database demonstrates that PLCE1 is frequently mutated gene in the different types of tumors (Figure 2A)

Clinical and translational studies have reported substantial changes in body weight and adipose tissue mass when the compound is evaluated in controlled trials and metabolic models, suggesting that multi-receptor agonism can alter energy balance through integrated endocrine signaling mechanisms [2][3][5]

always check with your health-care professional before changing medication or treating severe symptoms

I didnt feel any difference

However, researchers havent seen the same effect with orforglipron as with other weight loss drugs, but they are still monitoring it just in case