Therefore, we preformed DCFH-DA and C11-BODIPY staining followed by flow cytometry and found that WT ACTL6A reversed the increase in ROS levels (in cells treated with or without H 2 O 2 or both H 2 O 2 and NAC) and lipid peroxidation levels (in cells treated with or without erastin or both erastin and Fer-1), while ACTL6A HR-deleted mutant did not reverse these high levels (Fig
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It has no approval from regulatory agencies such as the FDA for human use and remains in the preclinical research phase
(1999) 277:L1138
Often referred to as the "master antioxidant," it is found in high concentrations in nearly every cell, particularly in the liver