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The sequence encoding full-length human Pol (Met 1-Glu335) was cloned into the SalI/NotI restriction sites of the pGEXT43(TEV) vector 41
The synergistic insulin secretion produced by simultaneous GIP and GLP-1 receptor activation is mechanistically distinct from what amylin/GLP-1 combinations provide, and the SURPASS trial data in diabetic populations is among the strongest in the field
[1] It tested once-weekly cagrilintide across a dose range and compared it with both placebo and an active comparator (liraglutide 3.0 mg)
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