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These investigations have examined the compound's biochemical effects in cultured cells and animal models as part of broader research into NNMT and cellular metabolism Importantly, these findings relate to preclinical research and should not be interpreted as evidence of established clinical efficacy, safety or therapeutic benefit in humans

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Established adipose tissue as a primary target organ for NNMT-inhibition research

TNF regulates cellular NAD+ metabolism in primary macrophages [PMID: 16516847] Laboratory literature summary: TNF regulates cellular NAD+ metabolism in primary macrophages

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