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Cardiovascular safety may be assessed either before or after authorisation, depending on the indication and the risk profile of the medicine this is determined on a case-by-case basis and is not universally required pre-authorisation, particularly for obesity indications

The program is not appropriate for every applicant

PDB 5F07 was used in molecular replacement to determine the starting phases for refinement with anisotropic B-factors and hydrogen atoms using MOLREP 67

Additionally, some individuals may notice changes in their sense of taste or feel tired

Future PCOS-specific economic studies should model not only weight and metabolic effects, but also fertility timing, washout-related delay, ART utilization, and potential rebound-related costs