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This is not extrapolation from animal models there is direct human evidence for the skin and healing claims
Understanding mechanism helps predict when something will work and when it wont
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Vitamin B12 is only found in animal-derived or fortified foods and can be depleted by certain medications such as metformin and proton-pump inhibitors
Future research applications will likely expand to include investigation of senescence heterogeneity, tissue-specific senescent cell populations, and the development of personalized approaches to senolytic intervention based on individual senescent cell burden and characteristics
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