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the EMA PRAC 2024 review found no causal link between licensed GLP-1 agonists and suicidal ideation, though this cannot be directly applied to retatrutide
Herbal Supplements and Kidney Disease
What Studies Show About Muscle Loss on GLP-1 Drugs The evidence on lean mass loss during GLP-1 therapy comes from the same large clinical trials that established these drugs as effective for weight loss
however, this analysis is limited by a large proportion of data missingness (Supplementary Table S1).The pattern of association of GLP1-RA with decreased acute healthcare utilization, CKD progression and all-cause death despite no difference in CV outcomes persisted in additional analyses excluding patients with ESRD (Supplementary Table S2) and after adjusting for A1c at follow-up and use of other anti-hyperglycemic medications (Supplementary Table S3)
PubMed NCBI. [Online]
