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+ Methionine It assists in the breakdown of fats and thereby prevents the build-up of fat in the arteries, as well as assisting with digestive system and removing heavy metals from the body since it can be converted to cytosine, which is a precursor to glutathione, which is of prime importance in detoxifying the liver

NNMT catalyzes transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine

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Awasthi S, Pandya U, Singhal SS, Lin JT, Thiviyanathan V, Seifert WE Jr, Awasthi YC, Ansari GAS (2000) Curcuminglutathione interactions and the role of human glutathione S-transferase P1-1

Donisi, 2025