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The study also found that most participants (87.7%) would not have met the eligibility criteria for the head-to-head randomised trial (SUSTAIN-7) that regulators originally used to compare these two drugs
Off-screen, the company compared the 42% of TV households that watched the Super Bowl last year to the 40% of U.S
Both medications work through entirely different mechanisms and are metabolised via separate pathways in the body, meaning they do not typically interfere with each other's effectiveness or safety profile
In the HER2-overexpressing cohort, drug-related ILD occurred in 20% of patients (3 patients with grade 5, 5 with grade 2, and 2 with grade 1) [33,35]
However, recent patient reports and clinical observations suggest a potential link between GLP-1 therapy and depression or emotional flattening, prompting important conversations about mental health screening before starting treatment
