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Similarly, the metal-responsive transcription factor MTF-1 accumulates in the nucleus upon zinc elevation, binding to metal-response elements to induce MT and other protective genes, thus forming a feedback loop that mitigates zinc excess 54,55

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Inflammatory cytokine (interleukins 1, 6 and 8 and tumor necrosis factor-alpha) release from cultured human fetal membranes in response to endotoxic lipopolysaccharide mirrors amniotic fluid concentrations

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