Lonborg and colleagues demonstrated a reduction in infarct size and increased myocardial salvage on exenatide administration in a randomized, placebo-controlled trial in human subjects with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention [65]
More receptor targets has meant more weight loss in trials so far but also, at the highest doses, more side effects and more discontinuations
This suggests that the co-treatment with ferrous iron again switched the signaling mechanisms and mode of cell death from mitochondrial dysfunction-dependent necrosis after APAP alone to LPO-dominated ferroptosis after APAP + Fe 2+ (Figure 1)
Players must differentiate not just on efficacy, but also on safety and tolerability, and convenience of use (e.g., oral vs injectable or weekly vs
Common side effects include mild nausea, lightheadedness immediately after the injection, and redness or bruising at the site