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However, for San385, the higher ECD dynamics were driven by increased flexibility of the bypass motif induced by the S19K San385 substitution

These findings, together with the very low plasma concentrations of Ang A, do not provide evidence for a physiological role of Ang A as a naturally occurring peptide, possibly counteracting the Ang II-mediated vasoconstrictor effects

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Others make early progress at 5 mg and then plateau

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