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The conservation of this regulatory axis is highlighted in other models

That said, mild side effects do occur in some people, and it's worth knowing how to manage them

This review highlights that NAD+ levels decline with age and play a critical role in metabolic and cellular health, with supplementation shown to raise NAD+ levels and potentially combat aspects of age-related decline

It also serves as a required substrate for two important families of enzymes: the sirtuins, which help regulate healthy cellular aging, and the PARPs, which help repair damaged DNA

Halestrap and Wilson, 2012