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Key points The incretins glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic peptide (GIP) and related hormones such as glucagon and amylin regulate metabolism, gastrointestinal motility, appetite and body weight

Holt et al., 2019)

Given the mechanism of action of retatrutide particularly its slowing of gastric emptying there is a plausible biological basis for acid reflux symptoms occurring in some individuals taking this medication, though a definitive causal link specific to retatrutide has not yet been established

Easier access to effective medications like semaglutide could improve long-term weight management, reduce obesity-related complications, and ease the burden on healthcare systems

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