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Celastrol, a natural compound, enhances HSP27 expression and reduces -synuclein and tau aggregation in PD and AD models
This is because alcohol acts as a direct irritant to your gastrointestinal tract - increasing the production of stomach acid, whilst also weakening the mucus layer that normally shields the stomach lining
CDX2 is also inhibited by SMYD2 -mediated MEX3A to enhance CRC progression (Pan et al., 2022), Decreased expression of CDX2 is more dependent on the CpG island hypermethylation phenotype (CIMP-H) (Lee et al., 2022)
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