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If you are experiencing moderate appetite reduction and eating 20-30% fewer calories than before, the medication is working

Taking a probiotic supplement containing Lactobacillus or Bifidobacterium species may help rebalance your microbiome toward non-sulfur-producing bacteria, though evidence remains mixed

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Assuming a 10% GLP-1 usage rate among overweight adults and a 20% usage rate among obese adults in the U.S., Roe (2025) estimates this could lead to a 3% reduction in total caloric demand, which amounts to 20 billion fewer calories of food consumed per day and about $1.2 billion less spent per week